M-aminophenol CAS NO.591-27-5

Using m-phenylenediamine as the starting reactant, m-aminoacetanilide hydrochloride was synthesized by monoamino salt formation and acetic anhydride monoacetylation, and then m-aminophenol was synthesized by diazotization and hydrolysis of diazonium salt. Process conditions for multi-step reaction: The optimal reaction conditions for the preparation of m-aminoacetanilide hydrochloride are: acetic anhydride: m-phenylenediamine = 1.1:1, 30% hydrochloric acid solution is added dropwise, and the reaction temperature is 40 ° C. Under the conditions, the yield is up to 92.5%; the optimum reaction conditions for the diazotization of m-aminoacetanilide hydrochloride: m-aminoacetanilide hydrochloride: sodium nitrite: sulfuric acid = 1:1.1:3, in 20% sulfuric acid In the medium, the reaction temperature is -10 ° C. Under the conditions, the diazonium salt synthesized by hydrolysis has the highest yield of meta-aminophenol, which is 70.5%, and the total yield of m-phenylenediamine is 65.2%. 99.9% .